Clinical evaluation of thioguanosine.
نویسندگان
چکیده
منابع مشابه
Clinical Evaluation of Thioguanosine*
~-Amino-6-mercapto-9fl-D-ribofuranosylpurine (thioguanosine) has been used orally and intravenously in the t reatment of 82 patients with leukemias and disseminated tumors. The oral dose of thioguanosine required to produce toxic or therapeutic responses was less than half the oral dose of thioguanine necessary to produce comparable results calculated on a molar basis. However, the two compound...
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The derivatives of 8-thioguanosine are thought to be included in the signal transduction system related to 8-nitroguanosine. In this study, we attempted to develop new 1,3-diazaphenoxazine (G-clamp) derivatives to covalently capture 8-thioguanosine (thioG-grasp). It was expected that the chlorine atom at the end of the linker would be displaced by the nucleophilic attack by the sulfur atom of 8...
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The growth of BHK-21/C13 cells in monolayer cultures was inhibited by 6-thioguanosine. Accumulation of putrescine, spermidine, and spermine was inhibited by 6-thioguanosine, and cells incubated in the presence of the drug had a decreased content of polyamines relative to control cells. These effects were more marked for spermidine than for spermine or putrescine. Consequently, the intracellular...
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The interaction of a series of chromophoric nucleotides derived from 6-mercapto-9-beta-ribofuranosylpurine (thioinosine, thiol) and 2-amino-6-mercapto-9-beta-ribofuranosyl-purine (thioguanosine, thioG) with myosin subfragment 1 isolated from rabbit skeletal muscle was investigated kinetically and spectroscopically. The Mg2+-dependent hydrolyses of thioITP and thioGTP are catalysed by subfragmen...
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Patients treated with the immunosuppressant and anticancer drugs 6-thioguanine, azathioprine, or mercaptopurine can metabolize and incorporate them in DNA as 6-thioguanosine. The skin of these patients is sensitive to UVA radiation, and long-term treatment can result in extremely high incidence of sunlight-induced skin cancer. In this contribution the photophysics of 6-thioguanosine have been s...
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عنوان ژورنال:
- Cancer research
دوره 21 شماره
صفحات -
تاریخ انتشار 1961